abstract：:Fatty acid-binding protein 3 (Fabp3) is an intracellular lipid trafficking protein that mediates energy metabolism and long-chain fatty acid-related signaling. Fabp3 is expressed in the spiral ganglion neurons and supporting cells of the organ of Corti. However, it is unclear what role Fabp3 plays in the cochlea. Here...

journal_title：Neuroscience research

authors： Suzuki J,Oshima T,Yoshida N,Kimura R,Takata Y,Owada Y,Kobayashi T,Katori Y,Osumi N

更新日期：2014-04-01 00:00:00

abstract：:Amyloid beta (Aβ) peptides are key molecules in the pathogenesis of Alzheimer's disease (AD). The sequential cleavage of amyloid precursor protein (APP) by the β- and γ-secretases generates Aβ peptides; however, the alternate cleavage of APP by the α- and γ-secretases decreases Aβ production. We previously reported th...

journal_title：Neuroscience research

authors： Yoshida H,Meng P,Matsumiya T,Tanji K,Hayakari R,Xing F,Wang L,Tsuruga K,Tanaka H,Mimura J,Kosaka K,Itoh K,Takahashi I,Imaizumi T

更新日期：2014-02-01 00:00:00

abstract：:Prenatal exposure to nicotine (PNE) has been associated with a myriad of physiological, cognitive, and behavioral effects in the developing offspring. In this study, CD-1 dams were given injections of nicotine or control vehicle throughout gestation and their offspring were raised to 6 months of age. Adult mice were a...

journal_title：Neuroscience research

authors： Santiago SE,Huffman KJ

更新日期：2014-02-01 00:00:00

abstract：:In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We specifically focus on recent developments in recording and stimula...

journal_title：Neuroscience research

authors： Borton D,Bonizzato M,Beauparlant J,DiGiovanna J,Moraud EM,Wenger N,Musienko P,Minev IR,Lacour SP,Millán Jdel R,Micera S,Courtine G

更新日期：2014-01-01 00:00:00

abstract：:Damage to the central nervous system (CNS) leads to the disruption of the axonal network and causes neurological dysfunction. Recovery of neurological functions requires restoration of the axonal network; however, injured axons in the adult mammalian CNS rarely regenerate after injury. Failure of the injured axon to r...

journal_title：Neuroscience research

authors： Muramatsu R,Yamashita T

更新日期：2014-01-01 00:00:00

abstract：:Recently the authors showed that a computational model of visual saliency could account for changes in gaze behavior of monkeys with damage in the primary visual cortex. Here we propose a neural prosthesis to restore eye gaze behavior by electrically stimulating the superior colliculus to drive visual attention. The s...

journal_title：Neuroscience research

authors： Yoshida M,Veale R

更新日期：2014-01-01 00:00:00

abstract：:This work was aimed to assess whether voluntary exercise rescued behavioral and hippocampal alterations in mice lacking the lysophosphatidic acid LPA1 receptor (LPA1-null mice), studying the potential relationship between the amount of exercise performed and its effects. Normal and LPA1-null mice underwent 23 days of ...

journal_title：Neuroscience research

authors： Castilla-Ortega E,Rosell-Valle C,Blanco E,Pedraza C,Chun J,Rodríguez de Fonseca F,Estivill-Torrús G,Santín LJ

更新日期：2013-11-01 00:00:00

abstract：:The present study investigated the effect of nicotine exposure on gustatory plasticity in the nematode Caenorhabditis elegans. The chemotactic response of wild-type N2 nematodes pre-exposed to 100mM NaCl with 3.0mM nicotine was almost the same as that of mock-conditioned nematodes unexposed to NaCl; however, the respo...

journal_title：Neuroscience research

authors： Matsuura T,Miura H,Nishino A

更新日期：2013-11-01 00:00:00

abstract：:Concurrent eye and hand movements toward a common visual target require different motor programs based on identical visual input. We used event-related brain potentials (ERP) to determine if and when the processing of the visual target differs for the two motor systems. The N2, an index for target evaluation, was more...

journal_title：Neuroscience research

authors： Wehrspaun CC,Pfabigan DM,Sailer U

更新日期：2013-09-01 00:00:00

abstract：:Growth hormone (GH) is a pleiotropic hormone that exerts important functions in the control of brain development as well as in the regulation neuronal differentiation and function, together with several behavioral and psychological effects that have been linked to its modulatory actions on brain neurotransmitters. In ...

journal_title：Neuroscience research

authors： Arce VM,Devesa P,Devesa J

更新日期：2013-08-01 00:00:00

abstract：:Since the first analysis of the Drosophila courtship song more than 50 years ago, the molecular and neural mechanisms underlying the acoustic communication between fruit flies has been studied extensively. The results of recent studies utilizing a wide array of genetic tools provide novel insights into the anatomic an...

journal_title：Neuroscience research

authors： Kamikouchi A

更新日期：2013-07-01 00:00:00

abstract：:How the nervous system controls the sensation and memory of information from the environment is an essential question. The nematode Caenorhabditis elegans is a useful model for elucidating neural information processing that mediates sensation and memory. The entire nervous system of C. elegans consists of only 302 neu...

journal_title：Neuroscience research

authors： Ohta A,Kuhara A

更新日期：2013-07-01 00:00:00

abstract：:The rats were subjected to 40 days of stress protocol, during which the sucrose consumption was assessed in rats chronically treated with lamotrigine (20mg/kg) or with saline. The signaling cascade and oxidative stress parameters were assessed in the brain rat. Both control and stressed rats treated with lamotrigine s...

journal_title：Neuroscience research

authors： Abelaira HM,Réus GZ,Ribeiro KF,Steckert AV,Mina F,Rosa DV,Santana CV,Romano-Silva MA,Dal-Pizzol F,Quevedo J

更新日期：2013-04-01 00:00:00

abstract：:The Approach-Avoidance Task (AAT) measures automatic approach-avoidance tendencies and their regulation: compatible reactions (approach positive, avoid negative) are faster than incompatible ones (approach negative, avoid positive). The present study assessed event-related potentials (ERPs) in 15 healthy persons for d...

journal_title：Neuroscience research

authors： Ernst LH,Ehlis AC,Dresler T,Tupak SV,Weidner A,Fallgatter AJ

更新日期：2013-03-01 00:00:00

abstract：:Recent advances in our understanding of brain function have come from using light to either control or image neuronal activity. Here we describe an approach that combines both techniques: a micromirror array is used to photostimulate populations of presynaptic neurons expressing channelrhodopsin-2, while a red-shifted...

journal_title：Neuroscience research

authors： Tsuda S,Kee MZ,Cunha C,Kim J,Yan P,Loew LM,Augustine GJ

更新日期：2013-01-01 00:00:00

abstract：:The neural pathways underlying the respiratory responses elicited by electrical or chemical stimulation of the lateral part of the periaqueductal gray (lPAG) remain unsettled. In the present study, we examined the lPAG projection to neurokinin-1 receptor (NK1R)-immunoreactive (ir) neurons in the ventrolateral medulla ...

journal_title：Neuroscience research

authors： Oka T,Yokota S,Tsumori T,Niu JG,Yasui Y

更新日期：2012-10-01 00:00:00

abstract：:ATP-sensitive K(+) (K(ATP)) channel subunits SUR2A and SUR2B in the rat brain were investigated by RT-PCR assay, western blot analysis, in situ hybridization histochemistry, and immunohistochemical staining. The results show that the mRNA and protein of SUR2A and SUR2B are expressed in whole rat brain extracts and sel...

journal_title：Neuroscience research

authors： Zhou M,He HJ,Tanaka O,Sekiguchi M,Kawahara K,Abe H

更新日期：2012-10-01 00:00:00

abstract：:It is well established that cholinergic modulation of functioning of neuronal networks is common in the central nervous system at all scales from neuronal columns to large nuclei. It is involved in various attentional, cognitive and behavioral performances. We have recently demonstrated that a frog retinotectal transm...

journal_title：Neuroscience research

authors： Baginskas A,Kuraite V,Kuras A

更新日期：2012-09-01 00:00:00

abstract：:Adult mammals could spontaneously achieve a partial sensory-motor recovery after spinal cord injury, by mechanisms including synaptic plasticity. We previously showed that this recovery is associated to the expression of synapsin-I, and that sonic hedgehog and Notch-1 could be also involved in plasticity. The role of ...

journal_title：Neuroscience research

authors： Gulino R,Gulisano M

更新日期：2012-07-01 00:00:00

abstract：:Following neonatal hypoxia-ischemia (HI) serotonin (5-hydroxytryptamine, 5-HT) levels are decreased in the brain. The regulation of brain 5-HT is dependent on the serotonin transporter (SERT) localised at the neuronal pre-synaptic cell membrane. However SERT can also traffic away from the cell membrane into the cytoso...

journal_title：Neuroscience research

authors： Wixey JA,Reinebrant HE,Buller KM

更新日期：2012-07-01 00:00:00

abstract：:TDP-43 pathology in motor neurons is a hallmark of ALS. In addition, the reduced expression of an RNA editing enzyme, adenosine deaminase acting on RNA 2 (ADAR2), increases the expression of GluA2 with an unedited Q/R site in the motor neurons of patients with sporadic ALS. As the occurrence of these two disease-speci...

journal_title：Neuroscience research

authors： Yamashita T,Hideyama T,Teramoto S,Kwak S

更新日期：2012-06-01 00:00:00

abstract：:We investigated brain activity in 3-5-year-old preschoolers as they listened to connected speech stimuli in Japanese (first language), English (second language), and Chinese (a rarely exposed, foreign language) using near-infrared spectroscopy. Unlike the younger preschoolers who had been exposed to English for almost...

journal_title：Neuroscience research

authors： Hidaka S,Shibata H,Kurihara M,Tanaka A,Konno A,Maruyama S,Gyoba J,Hagiwara H,Koizumi M

更新日期：2012-05-01 00:00:00

abstract：:The lateral olfactory tract (LOT) is a central olfactory pathway, and efferent projections from the olfactory bulb are conveyed to the olfactory-related cortical structures via the LOT. The purpose of the present study is to determine the exact site of the LOT causing functional impairment in animals. After ablation o...

journal_title：Neuroscience research

authors： Sekiguchi Y,Fukushima N,Yokouchi K,Kawagishi K,Hirayama S,Moriizumi T

更新日期：2012-05-01 00:00:00

abstract：:Action potentials, when arriving at presynaptic terminals, elicit Ca(2+) influx through voltage-gated Ca(2+) channels. Intracellular [Ca(2+)] elevation around the channels subsequently triggers synaptic vesicle exocytosis and also induces various protein reactions that regulate vesicle endocytosis and recycling to pro...

journal_title：Neuroscience research

authors： Yamashita T

更新日期：2012-05-01 00:00:00

abstract：:It has been postulated that horizontal cells (HCs) send feedback signals onto cones via a proton feedback mechanism, which generates the center-surround receptive field of bipolar cells, and color-opponent signals in many non-mammalian vertebrates. Here we used a strong pH buffer, HEPES, to reduce extracellular proton...

journal_title：Neuroscience research

authors： Kamiji NL,Yamamoto K,Hirasawa H,Yamada M,Usui S,Kurokawa M

更新日期：2012-04-01 00:00:00

abstract：:Changes in the expression of estrogen-related substances in monkeys' brains at the menopausal transition, when estrogen deficit starts to occur, have not yet been examined thoroughly. In the present study, we immunohistochemically investigated the expression levels of estrogen receptor beta (ERβ) and aromatase (local ...

journal_title：Neuroscience research

authors： Higaki S,Takumi K,Itoh M,Watanabe G,Taya K,Shimizu K,Hayashi M,Oishi T

更新日期：2012-02-01 00:00:00

abstract：:Amphibian metamorphosis is characterized by rapid tissue remodeling and drastic changes in the body structure and function. Like other organs, olfactory system also undergoes a dramatic rearrangement as the animal experiences transition from aquatic to terrestrial habitat. Reactive oxygen species (ROS) are known to pl...

journal_title：Neuroscience research

authors： Gaupale TC,Londhe J,Ghaskadbi S,Subhedar NK,Bhargava S

更新日期：2012-02-01 00:00:00

abstract：:Men and women exhibit differences in sexual behavior. This indicates that neural circuits within the central nervous system (CNS) that control sexual behavior differ between the sexes, although differences in behavior are also influenced by sociocultural and hormonal factors. Sexual differentiation of the body and bra...

journal_title：Neuroscience research

authors： Sakamoto H

更新日期：2012-02-01 00:00:00

abstract：:Acupuncture of the sacral vertebrae has therapeutic effects in patients with overactive bladders. The mechanism of these effects, however, remains unclear. The present study, using urethane-anesthetized rats, investigated the effects of acupuncture stimulation of the sacral vertebrae on bladder activity and bladder ac...

journal_title：Neuroscience research

authors： Wang H,Tanaka Y,Kawauchi A,Miki T,Kayama Y,Koyama Y

更新日期：2012-01-01 00:00:00

abstract：:Recent studies have shown that certain aromatic aldehydes are ligands for olfactory receptors expressed in mammalian sperm cells and induce sperm chemotaxis. Using a conditioning paradigm, the olfactory sensitivity of five CD-1 mice for seven aromatic aldehydes was investigated. With all seven stimuli, the mice discri...

journal_title：Neuroscience research

authors： Larsson L,Laska M

更新日期：2011-12-01 00:00:00

abstract：:We simulated brain lesions in mean diffusivity (MD) and fractional anisotropy (FA) images of healthy subjects to evaluate the performance of voxel-based analysis (VBA) with SPM2. We increased MD and decreased FA, simulating the most typical abnormalities in brain pathologies, in the superior longitudinal fasciculus (S...

journal_title：Neuroscience research

authors： Hiltunen J,Seppä M,Hari R

更新日期：2011-12-01 00:00:00

abstract：:The current study evidenced hypothesis that mitochondrial dysfunction-oxidative stress-dependent apoptotic pathways play a critical role in degeneration of dopaminergic neurons in Parkinson's disease. Model of rotenone-induced parkinsonism in rats produced decrease in striatal complex I activity and reduced glutathion...

journal_title：Neuroscience research

authors： Abdin AA,Sarhan NI

更新日期：2011-12-01 00:00:00

abstract：:One important aspect of empathy is a "resonance mechanism", which includes emotional cue detection, facial mimicry (measured by electromyography, EMG) and a specific cortical response. This study explored the convergence of these three measures of affective empathy. The twenty students who took part in the study were ...

journal_title：Neuroscience research

authors： Balconi M,Bortolotti A,Gonzaga L

更新日期：2011-11-01 00:00:00

abstract：:Subcortical vascular dementia (SVD) is a small vessel disease with dementia that exhibits relatively uniform clinical and pathological features and constitutes approximately half of vascular dementia (VaD) cases. This subtype is further classified into Binswanger's disease and multiple lacunar infarctions. The former ...

journal_title：Neuroscience research

authors： Tomimoto H

更新日期：2011-11-01 00:00:00

abstract：:The older neurocentric view of the central nervous system (CNS) has changed radically with the growing understanding of the many essential functions of astrocytes. Advances in our understanding of astrocytes include new observations about their structure, organization, function and supportive actions to other cells. A...

journal_title：Neuroscience research

authors： Barreto GE,Gonzalez J,Torres Y,Morales L

更新日期：2011-10-01 00:00:00

abstract：:Disrupted-in-Schizophrenia 1 (DISC1) is a susceptibility gene for major mental illnesses, including bipolar disorder and schizophrenia. Although the roles of DISC1 in nervous system development and functions are increasingly recognized, pathophysiological mechanisms underlying a range of neuropsychiatric symptoms caus...

journal_title：Neuroscience research

authors： Flores R 3rd,Hirota Y,Armstrong B,Sawa A,Tomoda T

更新日期：2011-09-01 00:00:00

abstract：:A broad range of neurodegenerative disorders result from the cytotoxicity conferred by aberrantly folded mutant proteins. Intriguingly, the cytotoxicity and aggregation property of a few mutant proteins are known to be modulated by the flanking sequences. One of such modulators is the proline repeat tract. Using a mam...

journal_title：Neuroscience research

authors： Siwach P,Sengupta S,Parihar R,Ganesh S

更新日期：2011-08-01 00:00:00

abstract：:Short-interval intracortical inhibition (SICI) acting on the first dorsal interosseus was measured using paired-pulse transcranial magnetic stimulation (interstimulus interval=2ms) in samples of young and healthy older subjects and correlated with manual dexterity measured with the Purdue Pegboard test and two isometr...

journal_title：Neuroscience research

authors： Marneweck M,Loftus A,Hammond G

更新日期：2011-08-01 00:00:00

abstract：:Accumulating evidence demonstrates astrocytic crucial roles in the brain, but the molecular basis underlying astrocytic intracellular protein trafficking remains to be elucidated. The present study reports the identification of novel protein, brain-derived integrating factor-1 (BDIF1), which comprises TBC (Tre-2/Bub2/...

journal_title：Neuroscience research

authors： Ito T,Ueki T,Furukawa H,Sato K

更新日期：2011-07-01 00:00:00

abstract：:The subgranular zone (SGZ) in the dentate gyrus contains radial astrocytes, known as Type-1 or Type-B cells, which generate neuroblasts (Type-2 cells or Type-D cells) that give rise to granular neurons. Stress increases glucocorticoid levels that target SGZ and modify the proliferation and apoptosis of hippocampal cel...

journal_title：Neuroscience research

authors： Gonzalez-Perez O,Chavez-Casillas O,Jauregui-Huerta F,Lopez-Virgen V,Guzman-Muniz J,Moy-Lopez N,Gonzalez-Castaneda RE,Luquin S

更新日期：2011-07-01 00:00:00